# News and views: lysine sorbylation enters the expanding universe of posttranslational modifications

## TL;DR

This paper discusses how lysine sorbylation, a new type of protein modification, is regulated by HDACs and affects inflammation gene expression.

## Contribution

The paper introduces lysine sorbylation as a novel posttranslational modification regulated by class I HDACs.

## Key findings

- Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs.
- Lysine sorbylation regulates the expression of inflammation-related genes.

## Abstract

Opinion Letter to Sin et al (Science Advances, 2025), Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genes.