# Cutaneous clues to a rare osseous manifestation of paracoccidioidomycosis: The importance of early diagnosis

**Authors:** Márcio Fellipe Menezes Viana, Rafael Fantelli Stelini, Andréa Fernandes Eloy da Costa França, Daniela Tsukumo Mitti, Luiz Fernando Monte Borella, Fabiano Reis

PMC · DOI: 10.1590/0037-8682-0232-2025 · Revista da Sociedade Brasileira de Medicina Tropical · 2025-10-17

## TL;DR

This case report highlights a rare bone manifestation of a fungal infection in a man, emphasizing the importance of early diagnosis through skin and bone evaluation.

## Contribution

The report presents a rare case of PCM with osteocutaneous involvement and underlines the role of dermatological assessment in diagnosis.

## Key findings

- A 47-year-old man was diagnosed with PCM through biopsy and fungal examination.
- Osteocutaneous PCM is rare and often mistaken for other conditions.
- Long-term antifungal treatment and follow-up are essential for management.

## Abstract

Paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Brazil, is caused by dimorphic fungi of the genus Paracoccidioides and is acquired primarily through inhalation. PCM is associated with a high mortality, particularly among men living in rural areas. This case report describes a 47-year-old man with osteocutaneous involvement diagnosed by biopsy and direct fungal examination. The osseous form of PCM is rare and should be differentiated from other infections and neoplasms. Management involves prolonged antifungal therapy and follow-up for at least two years. This case highlights the diagnostic value of dermatological assessments in atypical presentations of PCM.

## Linked entities

- **Diseases:** paracoccidioidomycosis (MONDO:0005894), PCM (MONDO:0005894)

## Full-text entities

- **Diseases:** neoplasms (MESH:D009369), mycosis (MESH:D015821), PCM (MESH:D010229), infections (MESH:D007239)
- **Species:** Paracoccidioides (genus) [taxon 38946], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12534022/full.md

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Source: https://tomesphere.com/paper/PMC12534022