# Combined SHR and SIRI biomarkers predict increased coronary heart disease risk in type 2 diabetes

## TL;DR

Combining two biomarkers, SHR and SIRI, improves detection of heart disease risk in people with type 2 diabetes.

## Contribution

The study introduces a novel combination of SHR and SIRI biomarkers for better coronary heart disease risk prediction in type 2 diabetes patients.

## Key findings

- SHR and SIRI are independently associated with coronary heart disease in type 2 diabetes patients.
- The combined SHR–SIRI model outperforms individual biomarkers in predicting heart disease risk.
- The model shows strong discrimination and calibration for risk stratification.

## Abstract

Coronary heart disease (CHD) is a leading cause of morbidity and mortality; patients with type 2 diabetes mellitus (T2DM) are at particularly high risk, highlighting the need for reliable biomarkers for early detection and risk stratification. We investigated whether combining the stress hyperglycemia ratio (SHR) and systemic inflammation response index (SIRI) improves CHD detection in T2DM. In this retrospective cohort of 943 T2DM patients undergoing coronary angiography, associations of SHR and SIRI with CHD were evaluated using multivariable logistic regression and restricted cubic splines; robustness was examined with subgroup and sensitivity analyses. Discriminative performance was assessed by receiver operating characteristic analysis and reclassification metrics (integrated discrimination improvement [IDI], net reclassification improvement [NRI]). Internal validation used bootstrapping, with calibration and discrimination yielding apparent and bias-corrected estimates. Of 943 patients, 600 had CHD. Multivariable models showed SHR (OR = 1.68; 95% CI, 1.14–2.46; P ═ 0.008) and SIRI (OR = 2.17; 95% CI, 1.54–3.05; P < 0.001) were independently associated with CHD, with nonlinear relationships (P for nonlinearity < 0.05). Findings were consistent across subgroups and sensitivity analyses. The combined SHR–SIRI model achieved an AUC of 0.813 (95% CI, 0.783–0.843), outperforming SHR alone (AUC = 0.773; 95% CI, 0.740–0.805) and SIRI alone (AUC = 0.745; 95% CI, 0.713–0.778), and significantly improved NRI and IDI (P < 0.05). All models showed strong discrimination and calibration. In conclusion, SHR and SIRI are independently associated with CHD in T2DM, and their combination enhances early identification of high-risk individuals.