# Eph-ephrin signaling and its potential role in female reproductive tract development

## TL;DR

This paper explores how Eph-ephrin signaling might influence the development of the female reproductive tract, based on clinical and animal studies.

## Contribution

The paper proposes a novel potential role for Eph-ephrin signaling in female reproductive tract development.

## Key findings

- Eph-ephrin signaling is known to be important in nervous and cardiovascular system development.
- Clinical evidence from Craniofrontonasal syndrome suggests a possible role in female reproductive tract development.
- Animal studies support the putative involvement of Eph-ephrin in reproductive tract development.

## Abstract

Eph-ephrin signaling plays crucial role in the development of nervous and cardiovascular system. Its role in female reproductive system development is unknown. Clinical observations in a rare developmental disorder, Craniofrontonasal syndrome, underscores the potential role of Eph-ephrin signaling in the development of female reproductive tract. In this minireview, the basics of Eph-ephrin signaling and its known role in development have been discussed. Putative role of Eph-ephrin in female reproductive tract development is discussed based on the available clinical evidence and animal studies.