# Successful Management of Cesarean Scar Ectopic Pregnancy Using Local Methotrexate Injection and Balloon Catheter Compression: A Case Report

**Authors:** Natalie M George, Madhav Barot, Reham Haroun

PMC · DOI: 10.7759/cureus.92400 · Cureus · 2025-09-15

## TL;DR

A rare case of ectopic pregnancy in a cesarean scar was successfully treated with methotrexate injection and balloon catheter compression.

## Contribution

This case report highlights a novel combination of medical and mechanical interventions for early-stage cesarean scar ectopic pregnancy.

## Key findings

- Ultrasound-guided methotrexate injection and balloon catheter compression led to a rapid decline in β-hCG levels.
- The treatment resulted in resolution of the ectopic pregnancy without surgical intervention.
- Early diagnosis and coordinated multidisciplinary care were critical to successful management.

## Abstract

Cesarean scar ectopic pregnancy (CSEP) is a form of non-tubal ectopic pregnancy. The diagnosis is made based on a combination of elevated beta human chorionic gonadotropin (β-hCG) levels and transvaginal ultrasound findings. In this case, a 32-year-old woman at 6.5 weeks gestation presented with abdominal cramping and vaginal bleeding. Transvaginal ultrasound confirmed a gestational sac implanted in the cesarean scar. After multidisciplinary consultation between obstetrics/gynecology and interventional radiology, the patient underwent ultrasound-guided intra-gestational methotrexate injection followed by balloon catheter compression. The results of the procedure included a rapid decline in β-hCG levels and resolution of the ectopic pregnancy. This case demonstrates the effectiveness of combining medical and mechanical interventions in early-stage CSEP and reinforces the importance of early diagnosis and coordinated care. Further research is needed to develop standardized treatment protocols for this rare condition.

## Linked entities

- **Chemicals:** methotrexate (PubChem CID 4112)
- **Diseases:** ectopic pregnancy (MONDO:0000755)

## Full-text entities

- **Diseases:** vaginal bleeding (MESH:D014592), CSEP (MESH:D011271), abdominal cramping (MESH:D003085), tubal ectopic pregnancy (MESH:D011274), scar (MESH:D002921)
- **Chemicals:** Methotrexate (MESH:D008727)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12532442/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12532442/full.md

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Source: https://tomesphere.com/paper/PMC12532442