# Do Aminopenicillins Have a Role in Treating Ampicillin-Resistant Enterococcus UTIs?

## TL;DR

This paper explores whether aminopenicillins can still be effective against Enterococcus UTIs that are resistant to ampicillin.

## Contribution

The paper evaluates the potential clinical efficacy of aminopenicillins despite ampicillin resistance in Enterococcus infections.

## Key findings

- Aminopenicillins may retain clinical efficacy even when susceptibility testing indicates resistance.
- Pharmacokinetic and pharmacodynamic data suggest a possible role for aminopenicillins in treating resistant infections.
- Risk-benefit considerations support re-evaluating aminopenicillins as treatment options.

## Abstract

Urinary tract infections caused by Enterococcus species are a frequent clinical challenge. The rising prevalence of ampicillin resistance often seemingly precludes the use of aminopenicillins. However, evidence suggests that aminopenicillins may retain clinical efficacy, even when susceptibility testing indicates resistance. Integrating available pharmacokinetics/pharmacodynamics and clinical data and risk-benefit considerations, we seek to address the question: Can aminopenicillins still be a viable treatment option in the management of ampicillin-resistant Enterococcus infections?