# False Discovery Estimation in Record Linkage

**Authors:** Kayané Robach, Michel H. Hof, Mark A. van de Wiel

PMC · DOI: 10.1002/sim.70292 · Statistics in Medicine · 2025-10-16

## TL;DR

This paper introduces a new method to estimate false discoveries in record linkage, improving reliability when combining data without unique identifiers.

## Contribution

A novel FDP estimation method for record linkage using synthetic data to assess linkage reliability across diverse settings.

## Key findings

- The method uses synthetic records to estimate false discoveries in record linkage.
- It works across various RL techniques and complex data settings.
- Applied successfully to the Netherlands Perinatal Registry to assess sibling links.

## Abstract

Integrating data from multiple sources expands research opportunities at low cost. However, due to different data collection processes and privacy constraints, unique identifiers are unavailable. Record linkage (RL) algorithms address this by probabilistically linking records based on partially identifying variables. Since these variables lack the strength to perfectly combine information, RL procedures yield an imperfect set of linked records. Therefore, assessing the false discovery proportion (FDP) in RL is crucial for ensuring the reliability of subsequent analyses. In this paper, we introduce a novel method for estimating the FDP in RL for two overlapping data sets. We synthesize data from their estimated empirical distribution and use it along with real data in the linkage process. Since synthetic records cannot form links with real entities, they provide a means to estimate the amount of falsely linked pairs. Notably, this method applies to all RL techniques and across diverse settings where links and non‐links have similar distributions–typical in complex tasks with poorly discriminative linking variables and multiple records sharing similar information while representing different entities. By identifying the FDP in RL and selecting suitable model parameters, our approach enables to assess and improve the reliability of linked data. We evaluate its performance using established RL algorithms and benchmark data applications before deploying it to link siblings from the Netherlands Perinatal Registry, where the reliability of previous RL applications has never been confirmed. Through this application, we highlight the importance of accounting for linkage errors when studying mother‐child dynamics in healthcare records.

## Full-text entities

- **Diseases:** bronchitis (MESH:D001991), paralysis (MESH:D010243), headaches (MESH:D006261), stroke (MESH:D020521), stillbirth (MESH:D050497), cancer (MESH:D009369), heart attack (MESH:D009203), numbness (MESH:D006987), preterm birth (MESH:D047928), scleroses (MESH:D012598), post-term birth (MESH:D000088562), diabetes (MESH:D003920), emphysema (MESH:D004646), flu (MESH:D007251), arteriosclerosis (MESH:D001161), pneumonia (MESH:D011014), congenital malformation (OMIM:163000), constipation (MESH:D003248), rheumatism (MESH:D012216), hypertension (MESH:D006973), epilepsy (MESH:D004827), Parkinson's disease (MESH:D010300), cerebral palsy (MESH:D002547), asthma (MESH:D001249), heart problems (MESH:D006331), glaucoma (MESH:D005901), overweight (MESH:D050177)
- **Chemicals:** synthpop (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12531477/full.md

## References

47 references — full list in the complete paper: https://tomesphere.com/paper/PMC12531477/full.md

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Source: https://tomesphere.com/paper/PMC12531477