# Syndrome of Inappropriate Anti‐Diuretic Hormone Secretion With Hyponatremia in Viral Encephalitis Patient: A Case Report

**Authors:** Juan Fu, Yan Zhao, Shuyi Li, Li Ren, Qingsong Wang, Binfeng He, Zaichun You

PMC · DOI: 10.1002/ccr3.71322 · Clinical Case Reports · 2025-10-16

## TL;DR

This case report describes a rare instance of inappropriate antidiuretic hormone secretion caused by viral encephalitis, highlighting the importance of early diagnosis and multidisciplinary care.

## Contribution

The paper presents a rare clinical case of SIADH linked to viral encephalitis, which is underrepresented in medical literature.

## Key findings

- SIADH caused by viral encephalitis was diagnosed after excluding other potential causes.
- Persistent dizziness and fatigue were the main symptoms in the elderly patient.
- Multidisciplinary collaboration was crucial for accurate diagnosis and treatment planning.

## Abstract

The syndrome of inappropriate antidiuretic hormone secretion is a condition marked by the excessive production of antidiuretic hormone, potentially resulting in hyponatremia. If not properly managed, severe hyponatremia can result in seizures, cerebral edema, and even death. There are many causes of this inappropriate release of antidiuretic hormone, including malignant tumors, central nervous system infections, drug‐induced factors, and hypothalamic–pituitary–renal axis disorders. Current evidence suggests that viral encephalitis‐related SIADH manifestations are markedly underrepresented in existing medical reports. We reported a case of elderly SIADH with persistent dizziness and fatigue as the main symptoms. Through multidisciplinary comprehensive analysis and discussion, and after excluding various factors, we considered it to be caused by viral encephalitis, which is rare in clinical practice. The SIADH is a clinically challenging disease that can severely impact a patient's health and quality of life. General practitioners need to consider multiple factors when diagnosing and treating this condition, leveraging their expertise, collaborating with multidisciplinary teams, and focusing on early identification and accurate diagnosis. They should develop individualized treatment plans and implement comprehensive management strategies to ultimately cure the patient.

## Linked entities

- **Diseases:** viral encephalitis (MONDO:0006009), syndrome of inappropriate antidiuretic hormone secretion (MONDO:0006802)

## Full-text entities

- **Genes:** AVP (arginine vasopressin) [NCBI Gene 551] {aka ADH, ARVP, AVP-NPII, AVRP, VP}
- **Diseases:** Hyponatremia (MESH:D007010), hypothalamic-pituitary-renal axis disorders (MESH:D007029), fatigue (MESH:D005221), death (MESH:D003643), malignant tumors (MESH:D009369), SIADH (MESH:D007177), dizziness (MESH:D004244), Viral Encephalitis (MESH:D018792), infections (MESH:D007239), seizures (MESH:D012640), cerebral edema (MESH:D001929)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12531350/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12531350/full.md

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Source: https://tomesphere.com/paper/PMC12531350