# Clinical efficacy of ERAS plus enteral nutrition in patients undergoing laparoscopic surgery for gynecologic malignancies

**Authors:** Huan Xia, Yaoyang Zhang, Cuiying Su, Min Zhou, Wenying Liu, Jiming Chen, Bingying Lu

PMC · DOI: 10.3389/fmed.2025.1576761 · Frontiers in Medicine · 2025-10-03

## TL;DR

This study shows that combining ERAS protocols with enteral nutrition improves recovery and reduces protein issues in gynecological cancer surgery patients.

## Contribution

The novel contribution is demonstrating the safety and efficacy of combining ERAS with enteral nutrition in gynecological malignancy surgery.

## Key findings

- Patients receiving ERAS plus enteral nutrition had higher postoperative protein and albumin levels.
- The study group showed significantly lower hypoproteinemia and earlier bowel recovery.
- Improved patient experience and reduced anxiety, thirst, and hunger scores were observed.

## Abstract

To enhance postoperative recovery in gynecological malignancies by evaluating the clinical efficacy and safety of Enhanced Recovery After Surgery (ERAS) combined with enteral nutrition.

This study included 127 patients with gynecological malignancies treated at Zigong Fourth People’s Hospital between January and December 2022. Based on patient preference, 60 were placed in the study group (ERAS + enteral nutrition) and 67 in the control group (traditional care). The two groups were compared on postoperative protein levels, electrolyte balance, and recovery indicators, including the time to first anal exhaust, defecation, and hospital stay duration. Additionally, preoperative thirst, hunger, anxiety scores, postoperative complications, and total hospitalization costs were evaluated.

The study group had higher postoperative total protein (66.59 ± 10.97 g/L) and albumin (43.47 ± 51.27 g/L) than the control group, with a significantly lower incidence of hypoproteinemia (18.33% vs. 50.75%, p < 0.05). There were no significant differences in hemoglobin, lymphocyte count, or electrolytes. The study group recovered bowel function earlier than the control group, with significant differences in defecation time (p < 0.05). No significant differences were observed in anal exhaust time, hospital stay, complications, or total costs. The study group had better anxiety, thirst, and hunger scores (p < 0.05).

ERAS combined with enteral nutrition is safe and effective for gynecological cancer surgery, reducing hypoproteinemia, promoting gastrointestinal recovery, and improving patient experience and psychological well-being.

## Full-text entities

- **Genes:** ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** hypoproteinemia (MESH:D007019), cancer (MESH:D009369), gynecologic malignancies (MESH:D005833), anxiety (MESH:D001007)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC12531206/full.md

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Source: https://tomesphere.com/paper/PMC12531206