# Possible Link Between Macrocytosis and Hypertriglyceridemia: A Case Report

## TL;DR

This case report suggests a possible link between high triglycerides and macrocytosis, a condition with enlarged red blood cells.

## Contribution

The paper introduces a potential novel association between hypertriglyceridemia and unexplained macrocytosis.

## Key findings

- A 75-year-old woman had persistent macrocytosis with no common causes identified.
- She had markedly elevated triglyceride levels, suggesting a possible link.
- Further research is needed to explore how triglycerides might affect red blood cell size.

## Abstract

Macrocytosis is relatively common and can be due to various etiologies. More common causes include vitamin B12/folate deficiency, liver disease, alcohol use, hypothyroidism, and myelodysplastic syndrome. A work-up often yields the etiology, but in some patients, it remains elusive. We present a case of a 75-year-old female with persistent and unexplained macrocytosis. A work-up for the common causes was unremarkable. However, she had a markedly elevated triglyceride level. This report implies a possible association between hypertriglyceridemia and macrocytosis. Further study is warranted to explore this relationship and red blood cell uptake of triglycerides.