# A Case of Psoriasis Concurrently Complicated by Sacroiliitis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

## TL;DR

A patient with psoriasis developed ME/CFS and sacroiliitis, suggesting a possible link between these conditions.

## Contribution

This case report highlights a concurrent occurrence of psoriasis, sacroiliitis, and ME/CFS, suggesting shared immunological mechanisms.

## Key findings

- Psoriasis exacerbation coincided with ME/CFS onset and sacroiliitis.
- Shared immunological abnormalities may link psoriasis and ME/CFS.

## Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a systemic chronic disorder characterized by persistent and unexplained severe fatigue. Recent population-based studies have revealed that patients with chronic inflammatory skin dermatoses, including psoriasis, are more likely to develop ME/CFS. Here, we report a case of psoriasis, whose exacerbation occurred concurrently with the development of sacroiliitis and the onset of ME/CFS. The pathogenesis of ME/CFS has not yet been fully elucidated, while inflammatory cytokines are involved in dysregulated interactions among the nervous, immune, and endocrine systems in the disease. We discussed the shared immunological abnormalities of psoriasis and ME/CFS based on previous literature. Our case contributes to the understanding of the association between psoriasis and ME/CFS.