# Diaphragm’s Role as a Systems-Connector Muscle: A Narrative Review

**Authors:** Bruno Bordoni, Bruno Morabito, Allan R Escher

PMC · DOI: 10.7759/cureus.94679 · Cureus · 2025-10-15

## TL;DR

This paper explores the diaphragm's complex role beyond respiration, emphasizing its broader systemic functions and challenging traditional views of its shape and movement.

## Contribution

The paper introduces a new hypothesis for describing the diaphragm's systemic functional complexity.

## Key findings

- The diaphragm's role extends beyond being a pump, impacting movement, cognition, and immunity.
- Three-dimensional studies show the diaphragm's shape remains unchanged during inflation.
- Functional assessment should focus on the diaphragm's movement rather than its morphology.

## Abstract

The diaphragm muscle (DM) is the most complex muscle in the entire musculoskeletal system, and it is associated with the most systemic actions. It is often labeled a pump, reflecting its role in the respiratory and circulatory systems. In reality, the DM's functions are broader, and the term "pump" does not adequately capture its importance. Clinically, DM is rarely considered to improve movement, cognitive and emotional functioning, or its influence on the immune response. Clinically and based on two-dimensional instrumental examinations, it is believed that DM "flattens" during inspiration or in the presence of chronic obstructive pulmonary disease (COPD). In contrast, we highlight, based on literature employing three-dimensional clinical instrumentation, that DM does not change its morphology during inflation. Therefore, the importance of DM functional assessment lies not in its shape but in its ability to move. To conclude, we propose a hypothesis for an adjective that best reflects the systemic functional complexity of DM.

## Linked entities

- **Diseases:** chronic obstructive pulmonary disease (MONDO:0005002)

## Full-text entities

- **Diseases:** Diaphragm (MESH:D065630), COPD (MESH:D029424)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12529849/full.md

## References

85 references — full list in the complete paper: https://tomesphere.com/paper/PMC12529849/full.md

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Source: https://tomesphere.com/paper/PMC12529849