# Benefits of P(LA/CL)‐Hyaluronic Acid Threads With Innovative Hyaluronic Acid Coating Technology (NAMICA)—Preclinical Test Results

## TL;DR

This study shows that new hyaluronic acid-coated threads improve skin rejuvenation by boosting collagen and reducing inflammation in pigs.

## Contribution

The novel NAMICA-coated P(LA/CL)-HA threads demonstrate enhanced biostimulation and biocompatibility compared to previous versions.

## Key findings

- P(LA/CL)+HA threads significantly increased collagen type I and III production with minimal inflammation.
- Elastin fiber content peaked at 180 days, and capsule thickness decreased over time, indicating better integration.
- The threads provide mechanical support and biochemical benefits, enhancing hydration and tissue regeneration.

## Abstract

To evaluate the biocompatibility and biostimulatory effects of P(LA/CL)‐Hyaluronic Acid Threads with Innovative Hyaluronic Acid Coating Technology (NAMICA) threads in a porcine model, focusing on collagen synthesis, hydration, and inflammatory response.

This study utilized a controlled laboratory setting to compare the safety and biostimulation capacity of the new P(LA/CL)‐HA threads produced with NAMICA technology against the previous generation thread. Threads were implanted into hybrid female pigs (Mangalitsa × Duroc), followed by histological analysis at 7, 21, 30, 90, and 180 days post‐implantation to assess collagen types I and III, elastin fibers, and tissue reaction.

P(LA/CL)+HA threads significantly enhanced collagen type I (mean 71.12%, up to 85.90%) and type III (mean 12.18%, up to 20.70%) with minimal inflammation. Elastin fiber content increased over time, with a peak of 2.82% at 180 days in subcutaneous tissue. Capsule thickness around P(LA/CL) threads decreased over time (from 64.28 to 27.23 μm), indicating improved integration.

The P(LA/CL)‐HA threads with NAMICA technology exhibit significant advantages in non‐surgical skin rejuvenation by combining mechanical support with biochemical benefits. They not only lift and volumize but also release hyaluronic acid gradually, enhancing tissue hydration and collagen production while minimizing inflammation. Further studies will validate these benefits in human subjects, potentially establishing new standards for aesthetic treatments.