# Analytical Application of an l‑Cysteine-Based Electrochemical Sensor for Quetiapine Determination in Pharmaceuticals

## TL;DR

This paper describes a new electrochemical sensor using l-cysteine to accurately measure quetiapine in pharmaceutical tablets.

## Contribution

The novel contribution is the development of an l-cysteine-based sensor for selective quetiapine quantification in pharmaceuticals.

## Key findings

- The sensor showed linearity for quetiapine concentrations between 8.05–85.0 μmol L–1.
- The detection limit was determined to be 1.17 μmol L–1.
- The sensor demonstrated successful applicability in pharmaceutical sample analysis.

## Abstract

The electropolymerization of l-cysteine was
applied for
the development of sensors to determine quetiapine in tablets. The
proposed sensor was characterized using electrochemical impedance
spectroscopy and applicability in the analysis of quetiapine by square
wave voltammetry. The electrocatalytic oxidation and pH effect of
quetiapine using the sensor were investigated through cyclic voltammetry.
The voltammetric peak currents, measured under optimized conditions,
exhibited linearity over the quetiapine concentration range of 8.05–85.0
μmol L–
1, with a detection limit
of 1.17 μmol L–
1. The proposed
poly­(l-cys)/GCE-based electrochemical sensor exhibited successful
applicability in the selective quantification of quetiapine within
pharmaceutical samples.