# Assessment of the feed additive neohesperidine dihydrochalcone (2b959) for piglets, pigs for fattening, calves, sheep, fish and dogs for the renewal of its authorisation (Adisseo S.A.S., ADM International Sàrl, Lucta S.A. and Norel S.A.)

**Authors:** Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Maria de Lourdes Bastos, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Maria Dulak‐Lis, Paola Manini

PMC · DOI: 10.2903/j.efsa.2025.9681 · EFSA Journal · 2025-10-16

## TL;DR

This paper assesses the safety and authorization renewal of neohesperidine dihydrochalcone, a feed additive, for various animals including pigs, calves, and fish.

## Contribution

The paper confirms the continued safety of neohesperidine dihydrochalcone without requiring re-evaluation of its efficacy.

## Key findings

- The additive remains safe for target species, consumers, and the environment.
- No modifications to the production process or efficacy were proposed.
- The additive is not irritating to skin or eyes and is not a skin sensitiser.

## Abstract

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for the renewal of the authorisation of neohesperidine dihydrochalcone as a sensory feed additive for piglets and pigs for fattening, calves, sheep, fish and dogs. The additive is already authorised for use in calves, sheep, fish, dogs and certain categories of pigs (2b959). The applicant provided evidence that the additive currently in the market complies with the existing conditions of the authorisation and that the production process has not been modified. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additive remains safe for the target species, consumers and the environment. Neohesperidine dihydrochalcone is not irritant to skin and eyes and is not a skin sensitiser. The present application for renewal of the authorisation does not include any modification proposal that would have an impact on the efficacy of the additive, and therefore, there is no need to re‐assess the efficacy.

## Linked entities

- **Chemicals:** neohesperidine dihydrochalcone (PubChem CID 30231)

## Full-text entities

- **Chemicals:** Neohesperidine dihydrochalcone (MESH:C013613)
- **Species:** Ovis aries (domestic sheep, species) [taxon 9940], Canis lupus familiaris (dog, subspecies) [taxon 9615], Sus scrofa (pig, species) [taxon 9823], Bos taurus (bovine, species) [taxon 9913]

## Full text

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12529050/full.md

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Source: https://tomesphere.com/paper/PMC12529050