# The roles of cell cycle proteins in regulating the tumor immune microenvironment

**Authors:** Qingbo Zhu, Xiaoli Wei, Ziting Qu, Lili Lu, Yiyin Zhang, Hua Wang

PMC · DOI: 10.1016/j.gendis.2025.101706 · Genes & Diseases · 2025-06-04

## TL;DR

This review explores how cell cycle proteins influence the tumor immune microenvironment and their potential in future immunotherapy.

## Contribution

It summarizes the mechanisms of cell cycle regulatory proteins in modulating the tumor immune microenvironment.

## Key findings

- Cell cycle proteins regulate immune cells and factors in the tumor immune microenvironment.
- These proteins may serve as therapeutic targets for next-generation antitumor immunotherapy.

## Abstract

Recent studies have shown that in addition to regulating the growth of tumor cells, cell cycle proteins can also regulate immune cells and factors in the tumor immune microenvironment (TIME), thus playing a role in regulating tumor immunity. This review summarizes the relevant mechanisms of cell cycle regulatory proteins in TIME regulation. The development of effective drugs against relevant therapeutic targets may be a hot research topic for the next generation of antitumor immunotherapy.

## Full-text entities

- **Diseases:** tumor (MESH:D009369)

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12528906/full.md

## References

137 references — full list in the complete paper: https://tomesphere.com/paper/PMC12528906/full.md

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Source: https://tomesphere.com/paper/PMC12528906