# The geroprotective potential of chalcones

## TL;DR

Chalcones, a type of plant compound, show promise in protecting against aging and extending lifespan in various species.

## Contribution

The paper highlights chalcones as novel geroprotective agents with potential for delaying aging-related diseases.

## Key findings

- 4,4’-dimethoxychalcone extends lifespan and provides geroprotection across species.
- Multiple chalcones exhibit anti-aging effects at both cellular and organismal levels.
- Mechanistic pathways involved in chalcone-induced geroprotection have been identified.

## Abstract

Aging is the most important risk factor for multiple pathologies including cardiovascular, neoplastic, metabolic and neurodegenerative diseases. Potential geroprotective strategies involve lifestyle-related, nutritional and pharmacological interventions. Recently, chalcones, a subgroup of secondary plant metabolites, have gained attention. 4,4’-dimethoxychalcone was the first chalcone to be shown to mediate geroprotection and lifespan extension across different species. Several other chalcones also exert anti-aging effects at the cellular and organismal levels. Defined mechanistic routes that are causally involved in these protective effects have been delineated. Here, we summarize current evidence supporting the potential of 4,4’-dimethoxychalcone and other chalcones as geroprotective agents.

Aging is driven by biological processes that can potentially be targeted by pharmacological interventions to delay its onset and extend healthspan. Here, the authors show the growing evidence supporting chalcones, a subgroup of secondary plant metabolites, as novel geroprotective agents