# Dyspepsia in nonagenarian women

## TL;DR

This study compares dyspepsia features in nonagenarian women and middle-aged women, finding differences in lab markers and gastric conditions.

## Contribution

The study pioneers the investigation of dyspepsia in nonagenarian women, revealing unique clinical and histopathological patterns.

## Key findings

- Nonagenarians showed higher rates of intestinal metaplasia and displasia.
- Nonagenarians had lower Helicobacter pylori infection rates compared to middle-aged women.
- Significant differences in multiple laboratory biomarkers were observed between the groups.

## Abstract

This study aims to investigate the clinical, laboratory, and histopathological features in women nonagenarians vs. middle-aged.

Significant differences were observed in several laboratory biomarkers such as leukocytes, neutrophils, glucose, creatinine, sodium, potassium, albumin, alanine transaminase, C-reactive protein, etc. between the groups (p < 0.05). Nonagenarians were less infected with Helicobacter pylori, whereas they had a higher frequency of intestinal metaplasia.

Nonagenarians group has a higher rate of intestinal metaplasia and displasia, while a lower rate of Helicobacter pylori infection in their gastric mucosal specimens. More extensive randomized controlled trials should illuminate the possible pathophysiological mechanisms for this association.

The online version contains supplementary material available at 10.1007/s41999-025-01197-w.

Dyspeptic complaints are common across all age groups, but limited research explores their characteristics and underlying pathologies in nonagenarians. This pioneering study aims to investigate the clinical, laboratory, and histopathological features in women nonagenarians vs. middle-aged.

A cross-sectional study included 93 female nonagenarians and 90 under 65 years (control), all presenting with dyspeptic complaints to general surgery, internal medicine, and gastroenterology outpatient clinics. Both groups underwent comprehensive evaluations, including laboratory parameters, upper gastric endoscopic examinations, and histopathological assessments of gastric biopsies. Statistical analysis compared the two groups' demographic, laboratory, and histopathological findings.

Of the patients included in the study, 49.8% were under 65 years, and 50.2% were nonagenarians. The mean age of the control group was 54.8 years, while nonagenarians had a mean age of 92.7 years. Significant differences were observed in several laboratory biomarkers such as leukocytes, neutrophils, glucose, creatinine, sodium, potassium, albumin, alanine transaminase, C-reactive protein, etc. between the groups (p < 0.05). Nonagenarians were less infected with Helicobacter pylori, whereas they had a higher frequency of intestinal metaplasia.

Nonagenarians group has a higher rate of intestinal metaplasia and displasia, while a lower rate of Helicobacter pylori infection in their gastric mucosal specimens. More extensive randomized controlled trials should illuminate the possible pathophysiological mechanisms for this association.

The online version contains supplementary material available at 10.1007/s41999-025-01197-w.