# Editorial: New avenues for the development of advanced immunotherapies: capitalizing on studies of the B and T cell receptor repertoire

**Authors:** Fabio Nicolini, Mar Naranjo Gomez, Mireia Pelegrin, Anna De Lucia, Lucia Mazzotti, Massimiliano Mazza

PMC · DOI: 10.3389/fimmu.2025.1693587 · Frontiers in Immunology · 2025-10-02

## Full-text entities

- **Genes:** CXADRP1 (CXADR pseudogene 1) [NCBI Gene 653108] {aka CAR, CXADRP}, KASH5 (KASH domain containing 5) [NCBI Gene 147872] {aka CCDC155, POF22, SPGF88}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, BCR (BCR activator of RhoGEF and GTPase) [NCBI Gene 613] {aka ALL, BCR1, CML, D22S11, D22S662, PHL}, PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2) [NCBI Gene 57546] {aka PDPC 2, PPM2B, PPM2C2}, TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}, GRB2 (growth factor receptor bound protein 2) [NCBI Gene 2885] {aka ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2}, GZMB (granzyme B) [NCBI Gene 3002] {aka C11, CCPI, CGL-1, CGL1, CSP-B, CSPB}, HAVCR2 (hepatitis A virus cellular receptor 2) [NCBI Gene 84868] {aka CD366, HAVcr-2, KIM-3, SPTCL, TIM3, TIMD-3}, IGH (immunoglobulin heavy locus) [NCBI Gene 3492] {aka IGD1, IGH.1@, IGH@, IGHD@, IGHDY1, IGHJ}, TIGIT (T cell immunoreceptor with Ig and ITIM domains) [NCBI Gene 201633] {aka VSIG9, VSTM3, WUCAM}, HLA-C (major histocompatibility complex, class I, C) [NCBI Gene 3107] {aka D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1}
- **Diseases:** uveal melanoma (MESH:C536494), ovarian cancer (MESH:D010051), autoimmune diseases (MESH:D001327), infectious disorders (MESH:D003141), ESCC (MESH:D004938), synovial sarcoma (MESH:D013584), viral infections (MESH:D014777), ascites (MESH:D001201), MM (MESH:D008545), cytotoxicity (MESH:D064420), oesophageal squamous cell carcinoma (MESH:D000077277), AD (MESH:D000544), Cancer (MESH:D009369)
- **Chemicals:** camrelizumab (MESH:C000631724), nivolumab (MESH:D000077594), platinum (MESH:D010984)
- **Species:** Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Homo sapiens (human, species) [taxon 9606], human gammaherpesvirus 4 (Epstein Barr virus, no rank) [taxon 10376]

## Full text

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## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12528009/full.md

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Source: https://tomesphere.com/paper/PMC12528009