# Successful Treatment of Vulvar Lichen Sclerosus Using Microfiltered and Preconditioned Suspension of Autologous Adipose‐Derived Stem Cells With Photothermal Biomodulation: A Case Report

**Authors:** Paolo Mezzana, Hernán Pinto

PMC · DOI: 10.1002/ccr3.71261 · Clinical Case Reports · 2025-10-15

## TL;DR

A new treatment using stem cells and light therapy successfully reduced symptoms of vulvar lichen sclerosus in a patient.

## Contribution

A successful case of vulvar lichen sclerosus treatment using adipose-derived stem cells and photothermal biomodulation is reported.

## Key findings

- Injections of microfiltered and preconditioned stem cells reduced symptoms and skin sclerosis.
- The treatment was well-tolerated with no side effects or complications.
- Positive results lasted for 5 months after treatment.

## Abstract

Vulvar lichen sclerosus is a chronic, inflammatory, autoimmune mucocutaneous disease characterized by hypopigmentation, skin sclerosis, and atrophy. Injections with microfiltered and preconditioned suspension of autologous adipose–derived stem cells are well tolerated and reduce symptoms and skin sclerosis without side effects or technical complications. Results are valid for 5 months after treatment (follow‐up period).

## Linked entities

- **Diseases:** vulvar lichen sclerosus (MONDO:0006491)

## Full-text entities

- **Diseases:** Vulvar Lichen Sclerosus (MESH:D007724), inflammatory (MESH:D007249), hypopigmentation (MESH:D017496), autoimmune mucocutaneous disease (MESH:D001327), atrophy (MESH:D001284), skin sclerosis (MESH:D012871)

## Full text

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## Figures

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## References

61 references — full list in the complete paper: https://tomesphere.com/paper/PMC12527820/full.md

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Source: https://tomesphere.com/paper/PMC12527820