# A Rare Case of Pyoderma Gangrenosum as a Complication of Ulcerative Colitis: A Case Report and Literature Review

**Authors:** Amin Shah, Anubhav Sharma, Agnimshwor Dahal, Prinsa Shrestha, Rahul Parajuli, Rebicca Pradhan, Bibek Shrestha

PMC · DOI: 10.1002/ccr3.71291 · Clinical Case Reports · 2025-10-15

## TL;DR

This paper reports a rare case of pyoderma gangrenosum linked to ulcerative colitis and emphasizes the importance of early diagnosis and treatment.

## Contribution

The novelty lies in highlighting a rare extraintestinal complication and its successful management in a patient with ulcerative colitis.

## Key findings

- Pyoderma gangrenosum was identified as a complication of ulcerative colitis in a patient with atypical skin ulcers.
- Early recognition and treatment with corticosteroids and immunosuppressive therapy improved patient outcomes.

## Abstract

This case highlights pyoderma gangrenosum, a rare but serious extraintestinal manifestation of ulcerative colitis, especially in patients presenting with atypical skin ulcers and a history of inflammatory bowel disease. The pathergy phenomenon and lesions were crucial diagnostic clues, and early recognition, along with prompt initiation of corticosteroids and immunosuppressive therapy, improved outcomes.

## Linked entities

- **Diseases:** pyoderma gangrenosum (MONDO:0018824), ulcerative colitis (MONDO:0005101)

## Full-text entities

- **Diseases:** Ulcerative Colitis (MESH:D003093), Pyoderma Gangrenosum (MESH:D017511), inflammatory bowel disease (MESH:D015212), skin ulcers (MESH:D012883)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12527817/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12527817/full.md

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Source: https://tomesphere.com/paper/PMC12527817