# Prevalence and clinical correlates of Peyronie’s disease in patients with Dupuytren’s disease: a cross-sectional study from a tertiary andrology center

## TL;DR

This study finds that Peyronie’s disease is common in men with Dupuytren’s disease, especially those with bilateral hand issues and poor blood sugar control.

## Contribution

The study is among the few to explore the prevalence and clinical correlates of Peyronie’s disease in Dupuytren’s disease patients using structured urological and metabolic evaluations.

## Key findings

- Peyronie’s disease was significantly associated with bilateral Dupuytren’s contracture and diabetes mellitus.
- Higher HbA1c and lower HDL cholesterol were linked to Peyronie’s disease in Dupuytren’s patients.
- Bilateral Dupuytren’s disease and HbA1c were independent predictors of Peyronie’s disease.

## Abstract

Dupuytren’s disease (DD) and Peyronie’s disease (PD) are fibroproliferative disorders that may share common pathophysiological mechanisms.

To determine the prevalence of PD among male patients diagnosed with DD and to investigate its clinical and laboratory correlates.

This cross-sectional observational study was conducted at a tertiary academic center and included 101 male patients diagnosed with DD. All participants underwent structured andrological evaluation and were classified into PD and non-PD groups. Clinical and laboratory parameters—including demographic, metabolic, sexual function, and inflammatory markers—were compared between the groups. Statistical analyses included descriptive statistics, Chi-square or Fisher’s exact tests for categorical variables, and Mann–Whitney U tests for continuous variables. Binary logistic regression was performed to identify independent predictors of concomitant PD.

The primary outcome was the prevalence of PD among patients with DD. Secondary outcomes included associations between PD and clinical/laboratory features.

PD was significantly associated with bilateral Dupuytren’s contracture (86.4% vs. 50.6%, P = 0.003), diabetes mellitus (81.8% vs. 44.3%, P = 0.003), lower high-density lipoprotein cholesterol (median 38 vs. 43 mg/dL, P = 0.030), higher fasting glucose (median 146 vs. 104 mg/dL, P = 0.018), and higher HbA1c (median 7.55% vs. 6.20%, P = 0.005).

Erectile function, assessed by the Erection Hardness Score, differed significantly between groups (median 3 in both; interquartile range: 2–3 in the PD group vs. 3–4 in the non-PD group, P = 0.007) (no significant differences were observed in the 6-item International Index of Erectile Function and the Sexual Health Inventory for Men scores).

In multivariate analysis, bilateral DD (OR = 17.80, P = 0.020) and HbA1c (OR = 1.589, P = 0.031) remained independently associated with PD. Other variables did not differ significantly between groups.

Male patients with DD—especially those with bilateral hand involvement or poor glycemic control—may warrant consideration for opportunistic urological evaluation to identify concomitant PD. However, further research is needed to determine the impact of early detection on patient outcomes.

This study is among the few to explore the prevalence and clinical correlates of PD in patients with DD, using a structured urological evaluation and comprehensive laboratory profiling. However, its cross-sectional design limits causal inference, and the single-center setting may affect the generalizability of the findings.

PD is highly prevalent among patients with DD, especially those with bilateral contracture and poor glycemic control. These findings support a possible systemic fibrotic predisposition and highlight the value of integrated metabolic and sexual health assessment in this population.