Multifunctional Polymer-Modified P-CaO2@Au@OVA@Cu@DHPs Nanoparticles Enhance SARS-CoV-2 mRNA Vaccine-Induced Immunity via the cGAS–STING Signaling Pathway
Yanle Zhi, Shengchao Wang, Haibo Zhang, Guimin Xue, Zhiqiang Zhang
TL;DR
Researchers developed a new nanoparticle platform that improves the effectiveness of SARS-CoV-2 mRNA vaccines by enhancing immune responses and sustained antigen release.
Contribution
A novel multifunctional nanoparticle platform was developed that acts as both an adjuvant and delivery system for mRNA vaccines.
Findings
The nanoparticles enhanced macrophage antigen uptake and antigen processing in vitro.
In vivo, the nanoparticles induced higher IgG levels and long-term immunity through sustained antigen release.
The platform showed robust adjuvant activity and potentiated both humoral and cellular immune responses.
Abstract
The success of mRNA-based SARS-CoV-2 vaccines has been confirmed in both preclinical and clinical settings. However, the development of safe and efficient mRNA vaccine delivery platforms remains challenging. In this report, PBAE-G-B-SS-modified CaO2 nanofibers and Au@OVA@Cu@Dendrobium huoshanense polysaccharides were employed to establish novel self-assembling polymeric micelles (CaO2@Au@OVA@Cu@DHPs) capable of serving as both an adjuvant and a delivery system for mRNA vaccines. In vitro, CaO2@Au@OVA@Cu@DHPs nanoparticles (NPs) were conducive to effective macrophage antigen uptake and efficient antigen processing. In vivo, P-CaO2@Au@OVA@Cu@DHPs NP administration was associated with a reduction in the ovalbumin (OVA) release rate that was conducive to the sustained induction of long-term immunity and to the production of higher levels of different IgG subtypes, suggesting that these…
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Taxonomy
TopicsSARS-CoV-2 and COVID-19 Research · Immunotherapy and Immune Responses · RNA Interference and Gene Delivery