# Click-Ready Gold Nanoparticles from Aqueous Mechanochemistry: 2-Propynylamine as a Reducing Agent and Surface Ligand

## TL;DR

A new method creates gold nanoparticles using 2-propynylamine, which both reduces gold and stabilizes the particles, making them ready for chemical reactions.

## Contribution

The use of 2-propynylamine as a dual-function reagent for synthesizing click-ready gold nanoparticles in a single step.

## Key findings

- Gold nanoparticles with an average diameter of 4.0 ± 1.0 nm were synthesized using 2-propynylamine.
- The nanoparticles have a surface plasmon resonance band at 520 nm and a terminal alkyne group for further modification.
- The method eliminates the need for external reducing or capping agents.

## Abstract

We report a rapid aqueous method for synthesizing monodisperse gold nanoparticles (AuNPs), employing 2-propynylamine as both an intrinsic reducing agent and a surface-stabilizing ligand. This self-mediated process—achieved in a single step—yields spherical AuNPs with an average diameter of 4.0 ± 1.0 nm and a well-defined localized surface plasmon resonance band centered at 520 nm. Acting as a bifunctional molecule, 2-propynylamine simultaneously reduces HAuCl4·3H2O to elemental gold and passivates the nanoparticle surface through coordination via the amine group, while preserving a terminal alkyne (–C≡CH) functionality. This reactive moiety remains exposed and chemically accessible, enabling post-synthetic modification through Cu(I)-catalyzed azide–alkyne cycloaddition. Control experiments using alternate milling times and vial composition confirmed the essential role of 2-propynylamine in mediating both reduction and surface functionalization. The resulting alkyne-functionalized AuNPs serve as versatile “click-ready” platforms for bioconjugation, sensing, and advanced material assembly. Overall, this scalable, green approach eliminates the need for external reducing or capping agents and provides a modular route to chemically addressable nanomaterials with tunable surface reactivity.