Green Synthesis and Characterization of Rosa roxburghii Tratt.-Mediated Gold Nanoparticles for Visual Colorimetric Assay of Tiopronin
Dan Liu, Shilan Feng
TL;DR
This study creates a simple and sensitive color-based test for tiopronin using gold nanoparticles made with Rosa roxburghii extract.
Contribution
The first use of Rosa roxburghii extract for green synthesis of gold nanoparticles for tiopronin detection.
Findings
RR-AuNPs showed a linear response to tiopronin concentrations from 0.17 μM to 16.67 μM.
The detection limit was as low as 0.19 μM, with successful application in urine samples.
The method is simpler and more sensitive than existing tiopronin detection techniques.
Abstract
This study used Rosa roxburghii Tratt. crude extract (RR) as a reducing, stabilizing, and modifying agent for the green synthesis of gold nanoparticles (RR-AuNPs) via the one-pot method for the first time and established a novel colorimetric sensor for detecting tiopronin. Initially, RR-AuNPs with a uniform particle size and stable dispersion were prepared using the reducing property of RR. Upon the introduction of tiopronin, the drug binds to the surface of RR-AuNPs through Au-S bonds and hydrogen bonds, inducing a significant aggregation of RR-AuNPs. The absorbance of the RR-AuNP solution exhibited a linear relationship with the tiopronin concentration in the range of 0.17 μM to 16.67 μM (y = 1.9157 − 0.0972x), with a detection limit of 0.19 μM. The colorimetric sensor was successfully applied to detect tiopronin in urine samples. Compared with other detection methods, this approach…
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Taxonomy
TopicsAdvanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis · Gold and Silver Nanoparticles Synthesis and Applications