A Pectin Polysaccharide from Arnebia szechenyi Kanitz and Its Digestion Product: Physicochemical Properties and Immunostimulatory and Antioxidant Activities
Surina Bo, Peng Zhao, Sarangua Ochir, Huiwen Pang, Mu Dan, Wenming Bai, Man Zhang, Jingkun Lu
TL;DR
A pectin polysaccharide from a plant root shows antioxidant and immune-boosting properties, which could lead to new drugs or food products.
Contribution
The study characterizes a novel pectin polysaccharide from Arnebia szechenyi Kanitz and demonstrates its immunostimulatory and antioxidant effects.
Findings
ASP is a pectin-like polysaccharide with a homogeneous molecular weight and specific sugar composition.
ASP and its digestion product D-ASP stimulate cytokine release and macrophage activity in a dose-dependent manner.
ASP has antioxidant activity and a branched structure that changes after digestion.
Abstract
The root of Arnebia szechenyi Kanitz, known as “Mongolia Zicao,” has been widely used in traditional Chinese and Mongolia medicine. Herein, we aimed to characterize a pectin polysaccharide extracted from A. szechenyi Kanitz root (ASP), elucidate its structure, and evaluate potential immunomodulatory activities through in vitro assays. Sugar composition analysis and high-performance gel permeation chromatography (HPGPC) revealed that ASP is predominantly composed of GalA (45.44%), Gal (22.13%), and Ara (19.86%) with a homogenous molecular weight of 18.4 kD. ASP was identified as a typical pectin-like polysaccharide containing linear HG domains and potentially linked to complex branches with Ara and Glu residues. The monosaccharide analysis of the digestion product, D-ASP, supported this hypothesis. The Congo red test indicated the absence of a triple-helix structure in ASP and its…
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Taxonomy
TopicsPolysaccharides and Plant Cell Walls · Polysaccharides Composition and Applications · Seaweed-derived Bioactive Compounds