Long Intergenic Non-Coding RNA 00511 (LINC00511) Genetic Variations and Haplotypes in Breast Cancer: A Case-Controlled Study and Bioinformatics Analysis

TL;DR

This study investigates how genetic variations in LINC00511 may influence breast cancer risk in the Egyptian population.

Contribution

The study identifies a specific SNP (rs11657109) in LINC00511 associated with increased breast cancer risk in Egyptians.

Findings

The TT genotype of rs11657109 significantly increases breast cancer incidence in the Egyptian population.

The SNP rs11657109 is specifically linked to luminal A breast cancer.

A specific haplotype of LINC00511 is strongly associated with increased breast cancer risk and is absent in controls.

Abstract

Long intergenic non-coding RNA 00511 (LINC00511) has been involved in the development of several types of cancer including breast cancer (BC). Several single nucleotide polymorphisms (SNPs) can be found in the genomic regions of long non-coding RNAs (lncRNAs) and are associated with the tumorigenesis of many cancers. The objective of the current study is to assess whether LINC00511 SNPs (rs11657109, rs9906859, rs17780195, rs1558535, and rs4432291) could be related with BC incidence in the Egyptian population. Five SNPs of LINC00511 were analyzed in a case–control study of 267 BC cases and 150 controls. Logistic regression analysis was used to test the association between LINC00511 SNPs and BC incidence. We found that the TT genotype of rs11657109 significantly increased BC incidence (OR: 2.177, 95%CI: 1.260–3.763) and this SNP was associated with high incidence of luminal A BC specifically using different genetic models. Haplotype (A09 A91 A35 G95 T59) was strongly associated with an increased BC incidence as it was totally absent in controls. These findings suggest that LINC00511 SNP rs11657109 is associated with BC susceptibility in the Egyptian population.

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