# To scale or not to scale? Re-engineering biorefining for a more sustainable and circular future

**Authors:** Ahmad B. Ghanayem

PMC · DOI: 10.1039/d5su90051d · 2025-10-15

## TL;DR

The paper discusses how sustainable biorefining needs a comprehensive approach to move from lab experiments to real-world applications.

## Contribution

The novelty lies in emphasizing a holistic process-level strategy combining techno-economic and life-cycle assessments for biorefining.

## Key findings

- Sustainable biorefining needs more than just renewable feedstocks.
- A holistic approach is essential for scaling up biorefining innovations.

## Abstract

Further to the use of renewable feedstocks, sustainable biorefining requires a holistic process-level approach encompassing techno-economic and life-cycle assessments to help bridge the gap between laboratory innovation and industrial scalability.

Further to the use of renewable feedstocks, sustainable biorefining requires a holistic process-level approach encompassing techno-economic and life-cycle assessments to help bridge the gap between laboratory innovation and industrial scalability.

## Full-text entities

- **Diseases:** toxicity (MESH:D064420)
- **Chemicals:** water (MESH:D014867), triglycerides (MESH:D014280), CO2 (MESH:D002245), ozone (MESH:D010126), glycerol (MESH:D005990), polystyrene (MESH:D011137), carbon (MESH:D002244), iron(iii) oxide (MESH:C000499), hydrogen cyanide (MESH:D006856), acetaldehyde (MESH:D000079), LA (MESH:D019344), polylactic acid (MESH:C033616), Styrene (MESH:D020058), PI (-), glucose (MESH:D005947), ethylbenzene (MESH:C004912), l-phenylalanine (MESH:D010649), vegetable oils (MESH:D010938)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12525052/full.md

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Source: https://tomesphere.com/paper/PMC12525052