# The Hidden Risks of Hip Replacement: Unveiling Mortality and Costs in 1.6 Million Patients

**Authors:** Yaron Berkovich, Binyamin Finkel, Assil Mahamid, Hadar Gan-Or, Loai Ahmad Takrori, Yaniv Yonai, David Maman

PMC · DOI: 10.3390/healthcare13192531 · Healthcare · 2025-10-07

## TL;DR

This study analyzed hip replacement outcomes in 1.6 million patients, identifying risk factors for mortality and increased costs.

## Contribution

The study provides a pre-pandemic national baseline for mortality and costs in elective hip replacements.

## Key findings

- Inpatient mortality was 0.04%, but higher in patients over 80, weekend admissions, and delayed surgeries.
- Comorbidities like heart failure and kidney disease significantly increased mortality and costs.
- Acute complications like pulmonary embolism led to higher costs and longer hospital stays.

## Abstract

Methods: Using the most recent pre-COVID National Inpatient Sample (2016–2019), we evaluated inpatient mortality and economic impact after elective primary total hip arthroplasty (THA) across 327,123 cases (1,635,615 weighted discharges).Results: Overall inpatient mortality was 0.04%, but was higher in patients ≥ 80 years (0.15%), with weekend admissions (0.10%), and with surgical delay ≥ 1 day (0.17%). Comorbidities with the greatest mortality association included congestive heart failure and chronic kidney disease (both with markedly elevated odds), and acute in-hospital complications (e.g., pulmonary embolism) carried substantial risk. Complications also increased resource use; for example, heart failure, pulmonary edema, and acute coronary artery disease were each associated with significantly higher costs and prolonged length of stay. Conclusion: These findings provide a contemporary, pre-pandemic national baseline that quantifies high-risk subgroups and the economic footprint of adverse events, supporting targeted perioperative strategies and hospital planning for elective THA.

## Linked entities

- **Diseases:** congestive heart failure (MONDO:0005009), chronic kidney disease (MONDO:0005300), pulmonary embolism (MONDO:0005279), heart failure (MONDO:0005252), pulmonary edema (MONDO:0006932)

## Full-text entities

- **Diseases:** pulmonary edema (MESH:D011654), Hip Replacement (MESH:D025981), chronic kidney disease (MESH:D051436), acute coronary artery disease (MESH:D054058), COVID (MESH:D000086382), congestive heart failure (MESH:D006333), pulmonary embolism (MESH:D011655), Complications (MESH:D008107)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12524541/full.md

## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12524541/full.md

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Source: https://tomesphere.com/paper/PMC12524541