# The Accessible Vascular Indicators for Mild Cognitive Impairment Detection: The Predictive Value of the Ankle-Brachial Index

## TL;DR

This study explores how the ankle-brachial index (ABI) can help detect early signs of cognitive decline, offering a simple and accessible diagnostic tool in primary care.

## Contribution

The study identifies ABI as a potential early predictor of mild cognitive impairment and neurocognitive disorders in primary care settings.

## Key findings

- Lower ABI values were associated with worse cognitive performance in participants.
- Pulse wave velocity (PWV) was not found to be a significant predictor of cognitive decline.
- Physical activity and mental well-being were linked to better cognitive outcomes.

## Abstract

Objectives: Neurocognitive disorders (NCDs) refer to a broad spectrum of conditions characterized by declining cognitive functions, such as memory, attention, language, and executive abilities. It is estimated that up to half of patients affected by NCDs remain undiagnosed or are diagnosed at an advanced stage of the disease. This study aimed to analyze the utility of subclinical organ damage markers, which could be used in primary care for the detection and prevention of NCD. Methods: The study participants (n = 137) completed neuropsychological tests (Addenbrooke’s Cognitive Examination/ACE and Mini-Mental State Examination/MMSE), a sociodemographic survey, an interview on past illnesses, and had their ankle-brachial index (ABI) and pulse wave velocity (PWV) values measured. Results: Based on the MMSE test, 26 participants (19.0%) were diagnosed with mild cognitive impairment (MCI) and 8 participants (5.8%) with NCDs. The study found that lower ABI values were associated with worse cognitive performance, suggesting that the ABI may be a useful tool for identifying individuals at increased risk of NCDs, while PWV cannot be used as a predictor for this group of diseases. Conclusions: Lower ABI values were associated with reduced cognitive performance, whereas PWV showed no significant relationship. The secondary findings suggest that physical activity, regular computer use, and better mental well-being were linked to improved cognitive outcomes. A low ABI value could potentially serve as a predictor of cognitive disorders, and as a diagnostic tool that is easily accessible and quick, it may improve diagnostics and the overall health of primary care patients. Health education regarding modifiable risk factors for dementia is also of crucial importance.