# Speculation on the Mechanism of Parkinson’s Disease Induced by Risk Residual Pesticides in Fresh Jujube and Hawthorn Through Network Toxicology and Molecular Docking Analysis

## TL;DR

This study explores how pesticide residues in jujube and hawthorn might contribute to Parkinson’s disease through toxicological and molecular analysis.

## Contribution

The novel approach combines network toxicology and molecular docking to investigate pesticide-induced Parkinson’s disease mechanisms.

## Key findings

- Pesticides like chlorpyrifos and cypermethrin may increase PD risk by affecting lipid metabolism.
- Molecular docking verified pesticide binding to PD-related proteins, suggesting neurotoxic potential.
- Network toxicology identified key pathways linking pesticide exposure to Parkinson’s disease.

## Abstract

Parkinson’s disease (PD) is a neurodegenerative disease that is closely related to genetic and environmental factors, among which pesticide exposure is considered an important risk factor. Fresh jujube and hawthorn, as widely consumed fruits, may contain pesticide residues, but the potential effects of long-term low-dose intake on PD are not yet clear. This study combines network toxicology and molecular docking technology to elucidate the molecular mechanism of PD induced by residual pesticides in fresh jujube and hawthorn. Firstly, common risk pesticides (such as organophosphates and pyrethroids) in fresh jujube and hawthorn were screened through the database. Subsequently, a “pesticide target—PD” interactive network was constructed using network toxicology to predict key targets and related pathways. Finally, molecular docking technology was used to verify the binding ability of pesticide molecules to PD-related proteins. The results indicate that some pesticides (such as chlorpyrifos and cypermethrin) may increase the risk of PD by affecting lipid metabolism and oxidative stress response. This study provides a new approach for assessing the neurotoxicity of pesticide residues and suggests the need to pay attention to the potential impact of dietary pesticide exposure on PD, providing a scientific basis for food safety regulation and PD prevention strategies.