# A Change of Hallmark: An Update

## TL;DR

This paper updates the understanding of non-angiogenic tumors and their growth patterns in various organs, along with treatment progress.

## Contribution

The paper provides an updated review of non-angiogenic tumor developments and modified cancer hallmarks over the last three years.

## Key findings

- Non-angiogenic tumors can grow by accessing existing blood vessels.
- Primary and metastatic tumors in the lung, liver, and brain are reviewed.
- Limited progress in treatment for non-angiogenic tumors is noted.

## Abstract

We review the latest development in non-angiogenic tumours. We focused on the last 3 years except the rarer tumours, for which the papers are older. Following the explanation of the modified hallmark of cancer, inducing angiogenesis and/or accessing vessels, the authors review primary and metastatic tumours growing into lung, liver and brain, plus oral cancer, lymphomas and node metastasis. Also progress in treatment, not many unfortunately, and techniques in non-angiogenic tumours are discussed.