# Efficacy of a Once-Daily Supplement in Managing Canine Chronic Kidney Disease

## TL;DR

A once-daily supplement improved kidney health and reduced complications in dogs with chronic kidney disease.

## Contribution

A convenient once-daily renal supplement was shown to effectively manage advanced canine CKD.

## Key findings

- The supplement reduced proteinuria, blood urea, and phosphorus levels in dogs with CKD.
- It stabilized creatinine and SDMA while improving inflammation and oxidative stress markers.
- Once-daily dosing improved compliance and was beneficial for dogs on multiple medications.

## Abstract

Chronic kidney disease (CKD) leads to irreversible loss of kidney function in dogs, often progressing with metabolic complications. This double-blind, randomized controlled study evaluated the efficacy of a once-daily renal supplement (Renal Combi, Candioli srl, Beinasco, Turin, Italy) in managing advanced CKD. Thirty dogs were enrolled and assigned to either a treatment or control group. Hematologic, biochemical, and urinalysis assessments were conducted throughout the study. The supplement demonstrated beneficial effects, including improved control of uremia, phosphate levels, blood pressure, inflammation, and oxidative stress. The simplified once-daily administration improved compliance, making it a practical adjunctive therapy for managing canine CKD.

Background: Chronic kidney disease (CKD) in companion animals leads to progressive renal deterioration and metabolic complications such as hyperphosphatemia and metabolic acidosis, particularly in advanced stages. Methods: This 90-day, double-blind, randomized controlled study evaluated the effects of a renal supplement (Renal Combi, Candioli srl, Beinasco, Turin, Italy) in 30 dogs diagnosed with CKD. Dogs were randomly assigned to a treatment group (TRT, n = 15), receiving a commercial renal diet plus the supplement (once daily), or a control group (CTR, n = 15), receiving the same diet and a placebo. Results: Results showed that supplementation effectively reduced proteinuria, blood urea, and phosphorus levels, stabilized creatinine and SDMA, and maintained blood pressure. It also improved markers of systemic inflammation and oxidative stress. Conclusions: The once-daily dosage simplified administration and was especially beneficial for hyporexic dogs or those on multiple medications. This study supports the use of the tested supplement as an effective adjunctive therapy for managing CKD in dogs, offering metabolic, renal, and nutritional benefits while enhancing compliance through convenient dosing.