Success Rates of Assisted Reproduction in Couples with Poor Ovarian Response and Oligospermia

TL;DR

The study examines how poor ovarian response and low sperm count affect the success of assisted reproduction, emphasizing the need for personalized treatment strategies.

Contribution

The study provides insights into managing couples with both poor ovarian response and oligozoospermia through personalized treatment approaches.

Findings

Oligozoospermia significantly reduces ICSI fertilization and cleavage rates.

Poor ovarian responders experience more cancelled cycles due to fewer embryos.

Personalized treatment approaches are necessary for couples with male factor infertility and poor ovarian response.

Abstract

Recent progress in assisted reproductive medicine has introduced novel therapeutic possibilities for couples experiencing various reproductive challenges or subfertility. A critical concern in this field is the diminished ovarian response to hormonal treatments preceding ovum pickup, necessitating personalised and optimised protocols to enhance ovarian response across different age groups. Furthermore, a common male factor in IVF couples, oligozoospermia, characterised by a low sperm count, significantly impacts the success rates of assisted reproductive technologies, posing an increasing challenge for in vitro fertilisation clinics. Lifestyle choices, dietary habits, and overall health behaviours have also demonstrably affected fertility outcomes in the 21st century. This original article aims to highlight the synergistic importance of both partners’ health, specifically addressing poor ovarian response and oligozoospermia, in achieving successful conception. Our study analysed intracytoplasmic sperm injection outcomes in couples affected by both aforementioned conditions and proposed an optimal management strategy. This study shows that oligozoospermia significantly reduced ICSI fertilisation and cleavage rates. Poor ovarian responders experienced more cancelled cycles due to fewer embryos. While blastocyst rates relative to zygotes were comparable, overall success was lower in groups with male factor infertility and poor ovarian response, necessitating personalised treatment approaches.

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