Proline Metabolism in Cancer: Emerging Roles in Redox Homeostasis and Therapeutic Opportunities
Tyrell C. Rossman, Gunjan Purohit, Oseeyi I. Daudu, Donald F. Becker
TL;DR
This paper reviews how proline metabolism supports cancer cell energy needs and explores its potential as a new target for cancer treatments.
Contribution
The paper highlights the emerging role of proline metabolism in cancer redox balance and therapeutic opportunities.
Findings
Proline metabolism is rewired in cancer to support energy production and redox homeostasis.
Proline metabolism varies across cancer subtypes, offering context-dependent therapeutic potential.
Targeting proline metabolism could lead to novel, precise cancer treatments.
Abstract
Cancer can cause uncontrolled cell growth and spread to distant locations within the body, which requires large amounts of energy. To acquire the needed energy, cancer cells alter signaling pathways and harvest nutrients from the surrounding environment. One pathway that has emerged to be rewired is proline metabolism, in which the amino acid proline is utilized for protein synthesis and is catabolized in the mitochondrion, driving ATP production and redox homeostasis involving the NAD+/NADH balance and reactive oxygen species. Cancer cells increase the efficiency of proline-dependent energy production by changing signaling pathways, coupling metabolic and redox cycles, and balancing collagen production and degradation. Because of the multiple roles of proline in cancer progression, targeting proline metabolism has gained strong interest as a novel approach for inhibiting cancer…
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Taxonomy
TopicsCancer, Hypoxia, and Metabolism · ATP Synthase and ATPases Research · RNA modifications and cancer