Jianpi Qutan Decoction improves hepatic lipid metabolism in atherosclerosis mice via PPARα-CPT1α pathway regulation
Xiaoyu Gao, Ying Hai, Dan Ma, Lisi Liu, Ying Pei, Jie Li, Wenping Wang
TL;DR
This study shows that Jianpi Qutan Decoction improves liver lipid metabolism in atherosclerosis mice by regulating the PPARα-CPT1α pathway.
Contribution
The study demonstrates a novel herbal treatment's mechanism for improving lipid metabolism in atherosclerosis via the PPARα-CPT1α pathway.
Findings
JPQT reduced hepatic triglycerides, cholesterol, and inflammation in atherosclerosis mice.
JPQT modulated fatty acid metabolism by promoting ACC phosphorylation and suppressing FAS and FFA.
JPQT upregulated PPARα, CPT1α, and ACOX1 expression in the liver in a dose-dependent manner.
Abstract
To investigate Jianpi Qutan Decoction (JPQT)’s effects on hepatic lipid metabolism via the PPARα-CPT1α pathway. Eight male C57BL/6J mice served as controls; 32 ApoE-/- mice were randomized into atherosclerosis (AS), atorvastatin calcium (AC), and low/medium/high-dose JPQT groups. Prior to the intervention, therapeutic targets of JPQT were analyzed using network pharmacology to provide a theoretical basis for subsequent experiments. The AS model was induced by a 12-week high-fat diet. Hepatic triglyceride (TG) and cholesterol (TC) were measured via GPO-PAP. Glucose tolerance (GTT) and insulin tolerance (ITT) were assessed. Pro-inflammatory cytokines were analyzed by ELISA/colorimetry. Fatty acid metabolism enzymes were evaluated using kits. PPARα-CPT1α pathway mRNA and protein expression were quantified via qPCR and Western blot. JPQT and AC reduced aortic plaque lipid deposition. JPQT…
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Taxonomy
TopicsPeroxisome Proliferator-Activated Receptors · Liver Disease Diagnosis and Treatment · Cancer, Lipids, and Metabolism