# A Rare Clinical Presentation of Malignant Pleural Mesothelioma With Central Nervous System Metastases: A Case Report

## TL;DR

A 63-year-old woman with malignant pleural mesothelioma developed rare central nervous system metastases, showing the aggressive and challenging nature of the disease.

## Contribution

This case report presents an unusual clinical presentation of MPM with CNS metastases in a female patient.

## Key findings

- The patient showed a partial response to cisplatin and pemetrexed chemotherapy.
- CNS metastases were detected months after treatment completion.
- Palliative radiotherapy provided only temporary control of neurological symptoms.

## Abstract

Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer arising from the pleural mesothelial cells, most often associated with long-term asbestos exposure. Symptoms are typically nonspecific, including shortness of breath, chest pain, and pleural effusion, which may delay diagnosis. We report a case of a 63-year-old woman with bilateral MPM and subsequent central nervous system (CNS) metastases. She received systemic chemotherapy with cisplatin and pemetrexed, achieving a partial radiological response. Several months after completing treatment, she developed neurological symptoms. Imaging revealed multiple CNS metastases. Palliative radiotherapy provided temporary control; however, her condition progressively deteriorated. This case illustrates an unusual presentation and metastatic pattern of MPM in a female patient, highlighting diagnostic and therapeutic challenges, as well as the aggressive nature of the disease despite palliative care.