# Switchable pathways of multicomponent heterocyclizations of 5-amino-1,2,4-triazoles with salicylaldehydes and pyruvic acid

## TL;DR

This paper shows how changing reaction conditions can switch the products formed from the same starting chemicals.

## Contribution

The study demonstrates a switchable pathway in multicomponent reactions using triazoles, pyruvic acid, and salicylaldehydes.

## Key findings

- Conventional heating produces benzotriazolooxadiazocine-5-carboxylic acids.
- Ultrasonic activation or room temperature stirring yields tetrahydrotriazolopyrimidine derivatives.

## Abstract

Switchable multicomponent reactions involving 3-substituted-5-amino-1,2,4-triazoles, pyruvic acid, and salicylaldehydes were studied under different conditions. Upon conventional heating, benzotriazolooxadiazocine-5-carboxylic acids were formed in the three-component reactions as single reaction products. Upon ultrasonic activation or mechanical stirring at room temperature, the multicomponent reaction of the same starting materials led to the formation of only tetrahydrotriazolopyrimidine derivatives.