Assessing the Potential of Caprine Collagen Type I in the Development of Medical Devices

TL;DR

This study compares collagen I from goat, pig, and cow tissues to evaluate their suitability for medical device scaffolds.

Contribution

The novel contribution is the comparative assessment of caprine collagen I scaffolds alongside porcine and bovine collagen I in terms of physicochemical and biological properties.

Findings

Caprine scaffolds had intermediate fibril diameters compared to porcine and bovine scaffolds.

Cross-linking significantly improved mechanical properties of all scaffolds.

Biological properties showed no significant differences between the groups.

Abstract

We isolated collagen I from caprine, porcine, and bovine
skin and
tendon tissues and assessed their purity and chemical properties.
We fabricated non-cross-linked and cross-linked scaffolds from each
collagen I preparation and assessed their physicochemical and biological
properties. Purity and chemical analyses did not reveal any notable
differences between the groups. Fibril diameter analysis revealed
that the non-cross-linked and cross-linked porcine, caprine, and bovine
preparations resulted in scaffolds with the thickest, intermediate,
and thinnest fibrils. Among the non-cross-linked scaffolds, no significant
differences were observed in stress at break between the groups and
the caprine scaffolds had significantly lower and higher strain at
break and Young’s modulus than the bovine and the porcine scaffolds.
Cross-linking significantly increased stress at break of all scaffolds,
strain at break of the caprine scaffolds, and Young’s modulus
of the bovine and porcine scaffolds. Biological analysis did not reveal
any noteworthy differences between the groups.

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