# The Effects of Chlorella vulgaris on Polycystic Ovary Syndrome in Mice

## TL;DR

This study shows that Chlorella vulgaris can reduce PCOS symptoms in mice by balancing hormones, reducing oxidative stress, and improving gut microbiota.

## Contribution

The novel contribution is demonstrating Chlorella's therapeutic effects on PCOS through hormonal, oxidative, and microbiota mechanisms in a mouse model.

## Key findings

- Chlorella reduced testosterone and luteinizing hormone levels in PCOS mice.
- Chlorella modulated oxidative stress-related genes and improved ovarian function.
- Chlorella restored gut microbiota composition disrupted by PCOS.

## Abstract

This study aimed to investigate the therapeutic effects of Chlorella on ovarian hormone levels, steroidogenic enzymes, ovarian dysfunction, oxidative stress, and gut microbiota composition in a mouse model of polycystic ovary syndrome (PCOS). A PCOS mouse model was established using dehydroepiandrosterone (DHEA) induction. The effects of Chlorella supplementation were evaluated in vivo to determine its potential for alleviating PCOS‐related symptoms. Chlorella treatment effectively reduced testosterone (T) and luteinizing hormone (LH) levels in mice with PCOS. Additionally, Chlorella modulated the expression of oxidative stress‐related genes and improved ovarian morphology and function. Notably, Chlorella also restored the gut microbiota from PCOS‐associated dysbiosis. Chlorella ameliorated PCOS symptoms by rebalancing ovarian steroid hormones, enhancing antioxidant defense, and modulating the gut microbiota. These findings support its potential as a natural therapeutic agent for PCOS management.

A mouse model of polycystic ovary syndrome was successfully induced in our experiments. Therapeutic effects of chlorella algal powder as a functional food to some extent in a mouse model of polycystic ovary syndrome.