Dust Mite Serodominance Profiles in Lugo

TL;DR

This study examines dust mite allergy profiles in 50 patients, finding high sensitization rates to specific mite allergens, particularly Der p2 and Der p23.

Contribution

The study identifies Der p23 as a highly prevalent allergen and highlights its association with asthma.

Findings

96% of patients had a positive skin prick test to dust mites, with Der p2 being the most prevalent allergen.

Der p23 sensitization was high (72%) and all asthmatic patients were sensitive to Der p2.

Non-asthmatic patients showed reduced sensitivity to Der p23 compared to asthmatic patients.

Abstract

House dust mite allergy affects 65–130 million people worldwide. Untreated patients could develop severe allergic diseases such as atopic dermatitis and asthma.

We consecutively recruited 50 patients with a clinical diagnosis of allergic rhinitis/rhino conjunctivitis. Mite Skin Prick Tests were performed. Mite specific IgE were tested.

Ninety‐six per cent of the patients had a positive prick test for Dpt, Dfar 94%, Ldt 86%, Tput 82%, and Blot 82%. Der p1 was recognized by 70%, Der p2 84%, Der p23 72%. Regarding serodominances, Der p2 was the highest one (30.2 kU/L). Forty‐three patients presented sensitization to 3 Dermatophagoides pteronyssinus molecules, been 1 + 2 + 23 the main combination. Der p 1, 2, and 23 prevalence were similar in patients with intermittent or persistent allergic rhinitis. All patients with asthma recognized to Der p2 and more than 80% Der p1 and 23. In the group of patients without asthma, sensitivity to Der p23 is considerably reduced.

Ninety per cent of patients recognize Der p1, 2, and 23, alone or in any of their combinations. The high prevalence of sensitization to Der p23 (72%) stands out, that all asthmatic patients are sensitive to Der p2 and that sensitization to Der p23 in non‐asthmatic patients drops to 50%.

We consecutively recruited 50 patients with a clinical diagnosis of allergic rhinitis/rhino conjunctivitis. Der p1 was recognized by 70%, Der p2 84%, Der p23 72%.

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