# Under‐Interpretation of Neuroimaging Data in Insanity Assessment: A Hidden Risk

**Authors:** Camilla Frangi, Alexa Schincariol, Pietro Pietrini, Giuseppe Sartori, Stefano Ferracuti, Cristina Scarpazza

PMC · DOI: 10.1002/bsl.70006 · 2025-07-02

## TL;DR

This paper highlights the risk of under-interpreting neuroimaging data in legal insanity assessments, using an Italian case to show how it can lead to errors.

## Contribution

The paper introduces the concept of under-interpretation as a critical but overlooked issue in forensic neuroscience.

## Key findings

- A defendant's brain abnormalities were misinterpreted as normal, affecting the insanity evaluation.
- Under-interpretation of neuroimaging data can lead to flawed legal decisions.
- A multidisciplinary approach is recommended to reduce errors in insanity assessments.

## Abstract

Neuroimaging data can provide valuable insights into insanity evaluations, but the debate over its use for legal purposes is far from resolved. While much attention has been given to the risks of over‐interpretation, potential errors stemming from under‐interpretation received less scrutiny. In this paper, we aim to showcase how this error may influence the results of an insanity evaluation by presenting an Italian forensic case. The defendant presented with intellectual disability and psychotic symptoms coupled with multiple brain abnormalities that were interpreted as variant of normal neuroanatomy. The case is discussed in detail. This article offers an insight into a neglected issue in forensic neuroscience, destined to gain prominence as this discipline becomes increasingly important in criminal justice systems worldwide. We recommend the use of a multidisciplinary approach to insanity to reduce the likelihood of error. In this context, neuroimaging can play an important role, and its interpretation should strictly adhere to guidelines to minimize the possibility of both over‐interpretation and under‐interpretation.

## Linked entities

- **Diseases:** intellectual disability (MONDO:0001071)

## Full-text entities

- **Diseases:** brain abnormalities (MESH:D001927), psychotic symptoms (MESH:D011618), intellectual disability (MESH:D008607)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12521884/full.md

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Source: https://tomesphere.com/paper/PMC12521884