# Pertussis in Infancy: A Case of Delayed Diagnosis

**Authors:** Azary Hernandez, Jean Paul Ambroise, Ana M Hernandez-Puga

PMC · DOI: 10.7759/cureus.92322 · 2025-09-14

## TL;DR

A 13-month-old child was misdiagnosed with a viral infection before being correctly diagnosed with pertussis, highlighting the need for early recognition and vaccination.

## Contribution

The case emphasizes the importance of timely diagnosis and vaccination awareness to prevent severe complications.

## Key findings

- Early symptoms of pertussis can mimic viral infections, leading to delayed diagnosis.
- Timely PCR testing confirmed the diagnosis after the characteristic cough appeared.
- Prophylactic treatment was administered to close contacts to prevent further spread.

## Abstract

Bordetella pertussis is a gram-negative bacterium that primarily infects the respiratory tract. We report the case of a 13-month-old male patient who developed pertussis. At the initial clinic presentation, the diagnosis was not immediately considered, as the early manifestations closely mimicked those of a viral upper respiratory infection. As the illness progressed, the classic paroxysmal cough with inspiratory “whoop” became apparent, prompting the correct diagnosis. At that time, a nasopharyngeal swab was obtained, which tested positive for Bordetella pertussis by polymerase chain reaction (PCR). The patient was prescribed a five-day course of azithromycin, and close contacts were given prophylactic treatment.

This case underscores the critical importance of early recognition and timely diagnosis to prevent potentially life-threatening complications. It also highlights the necessity of vaccination awareness. Educating parents and caregivers on the benefits of immunization against vaccine-preventable diseases is essential to safeguard vulnerable individuals and to promote community-wide protection through herd immunity.

## Linked entities

- **Chemicals:** azithromycin (PubChem CID 447043)
- **Diseases:** pertussis (MONDO:0005077)
- **Species:** Bordetella pertussis (taxon 520)

## Full-text entities

- **Diseases:** Pertussis (MESH:D014917), upper respiratory infection (MESH:D012141), cough (MESH:D003371)
- **Chemicals:** azithromycin (MESH:D017963)
- **Species:** Homo sapiens (human, species) [taxon 9606], Bordetella pertussis (species) [taxon 520]

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Source: https://tomesphere.com/paper/PMC12521777