Lofgren Syndrome in a 35‐Year‐Old Female: A Case Report

TL;DR

A 35-year-old woman from Ethiopia was diagnosed with Lofgren syndrome, a rare form of sarcoidosis, and showed quick improvement with low-dose prednisolone.

Contribution

This case report adds to the limited literature on Lofgren syndrome in young female patients from Ethiopia.

Findings

The patient exhibited classic symptoms of Lofgren syndrome, including arthritis, fever, and erythema nodosum.

Chest imaging confirmed hilar and mediastinal lymphadenopathy, supporting the diagnosis.

Low-dose prednisolone led to rapid clinical improvement.

Abstract

Lofgren syndrome is an acute and pathognomonic form of sarcoidosis characterized by fever, hilar lymphadenopathy, arthritis, and erythema nodosum (EN). We report a 35‐year‐old female patient from Ethiopia who presented with a 4‐day history of arthritis involving bilateral ankles, knees, and wrists associated with fever and skin lesions typical of EN. Chest imaging (X‐ray and computed tomography (CT) scan) revealed bilateral hilar and mediastinal lymphadenopathy as well as perilymphatic nodules in the mid and upper zones of both lungs. Workup for alternative diagnoses, including tuberculosis, was negative. After the diagnosis of Lofgren syndrome was made, she was started on a low dose of prednisolone, which resulted in a prompt and marked improvement in her symptoms.

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