# Bioadhesive and conformable bioelectronic interfaces for vasomotoricity monitoring and regulation

## TL;DR

A new bioelectronic interface is developed to monitor and regulate blood vessel activity, offering insights into vascular health and potential treatments.

## Contribution

A bioadhesive and conformable bioelectronic interface for monitoring and modulating vasomotoricity is introduced.

## Key findings

- The interface adheres to cylindrical surfaces in aqueous conditions for up to two months.
- It enables precise recording of vasomotor states with low impedance and background noise.
- The system can detect and modulate vasomotor dysfunction to restore vascular elasticity.

## Abstract

The autonomic nervous system (ANS) dynamically regulates vasomotor function to maintain vascular homeostasis, yet current clinical tools lack the capacity to capture its electrophysiological basis, particularly following stent implantation. Herin, we report a bioadhesive and conformable bioelectronic (BACE) interface engineered for effective monitoring and modulation of vasomotoricity. Incorporating silk fibroin-based adhesives, the interface adheres robustly to cylindrical surfaces in aqueous conditions for up to two months. It exhibits low interfacial impedance (6.77 ± 2.13 kΩ at 1 kHz) and background noises (2.63 ± 0.52 μV) in vivo, enabling precise recording of varying vasomotor states. In a stent model, the interface identifies alterations in bioelectrical activity associated with vasomotor dysfunction, validated against ultrasound-derived arterial stiffness as clinical gold standards. Furthermore, we demonstrate a bidirectional system for the detection and modulation of dysfunction to restore vasomotor activity and elasticity. These findings provide insights into vasomotor electrophysiology mechanisms and underscore the therapeutic potential of bioelectronic modulation in vascular disease.

Vasomotor function is regulated by the autonomic nervous system, but its electrophysiological basis remains poorly captured, especially post-stenting. Here, the authors develop a bioadhesive bioelectronic interface for precise monitoring and modulation of vasomotor activity.