# Associations between pain, anxiety and depression and mindfulness in patients with burning mouth syndrome: a cross-sectional study

**Authors:** Jing He, Junjiang Liu, Xin Ye, Mingjia Hu, Ning Xiao, Jia Li, Yansong Song, Fanglong Wu, Fan Liu

PMC · DOI: 10.22514/jofph.2025.053 · Journal of Oral & Facial Pain and Headache · 2025-09-12

## TL;DR

This study finds that mindfulness is linked to lower pain and fewer anxiety and depression symptoms in patients with burning mouth syndrome.

## Contribution

The study explores the specific role of mindfulness facets in managing pain and psychological symptoms in burning mouth syndrome patients.

## Key findings

- Higher overall mindfulness is associated with lower pain intensity in BMS patients.
- The 'non-judging' and 'non-reactivity' mindfulness facets are linked to fewer anxiety symptoms.
- The 'acting-with-awareness' facet is associated with fewer depressive symptoms.

## Abstract

Background: Burning mouth syndrome (BMS) is a chronic pain disorder 
affecting the oral mucosa, often accompanied by psychological comorbidities. 
Higher levels of mindfulness have been associated with reduced pain and fewer 
emotional symptoms in some chronic pain conditions, but its role in BMS remains 
inadequately explored. Methods: 146 patients diagnosed with BMS, 
according to the International Classification of Orofacial Pain, 1st edition, 
were recruited from the Department of Oral Medicine at a stomatology hospital. 
Mindfulness, pain intensity and psychological symptoms were assessed using the 
Five Facet Mindfulness Questionnaire, visual analog scale, and self-report 
screening tools, respectively. Spearman’s correlation and multiple regression 
analyses were conducted to evaluate the relationships between mindfulness and 
levels of pain, anxiety, and depression. Results: Mindfulness showed 
significant negative correlations with pain (r = −0.204, p < 
0.05), anxiety (r = −0.309, p < 0.01), and depression 
(r = −0.299, p < 0.01). After controlling for confounding 
variables, higher overall mindfulness remained significantly associated with 
lower pain intensity (β = −0.268, p < 0.05), although the 
associations with anxiety and depression were no longer statistically significant 
(p > 0.05). Among the mindfulness facets, higher scores on the 
“describing” facet were associated with reduced pain intensity (β = 
−0.231, p < 0.05). Additionally, higher scores on the “non-judging” 
(Odds Ratio (OR) = 0.871, p < 0.05) and “non-reactivity” 
(OR = 0.869, p < 0.05) facets were associated with fewer anxiety 
symptoms, while the “acting-with-awareness” facet was significantly associated 
with fewer depressive symptoms (OR = 0.869, p < 0.05). 
Conclusions: The overall mindfulness level and the “describing” facet 
appear to be associated with pain severity, whereas the “non-judging” and 
“non-reactivity” facets are related to anxiety symptoms, and the 
“acting-with-awareness” facet is linked to depressive symptoms, suggesting that 
mindfulness-based interventions may offer a beneficial approach in the management 
of BMS.

## Linked entities

- **Diseases:** Burning mouth syndrome (MONDO:0006687)

## Full-text entities

- **Diseases:** Orofacial Pain (MESH:D005157), anxiety symptoms (MESH:D001008), depression (MESH:D003866), anxiety (MESH:D001007), BMS (MESH:D002054), chronic pain (MESH:D059350), pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

48 references — full list in the complete paper: https://tomesphere.com/paper/PMC12520433/full.md

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Source: https://tomesphere.com/paper/PMC12520433