# Robotic-Assisted Lobectomy Following Induction Chemoimmunotherapy Achieves Complete Pathologic Response in Stage IIIA Lung Adenocarcinoma: A Case Report

**Authors:** Kendall Howard, Ray Chihara, Warren C Naselsky, Min P Kim

PMC · DOI: 10.7759/cureus.92285 · Cureus · 2025-09-14

## TL;DR

A 77-year-old woman with stage IIIA lung cancer achieved complete tumor removal after chemoimmunotherapy and robotic surgery.

## Contribution

This case demonstrates complete pathologic response after chemoimmunotherapy and robotic lobectomy in stage IIIA lung cancer.

## Key findings

- Neoadjuvant chemoimmunotherapy reduced tumor size in a stage IIIA lung cancer patient.
- Robotic lobectomy following therapy resulted in complete pathologic response with no residual tumor.
- Combination therapy and surgery offer potential cure for advanced lung cancer.

## Abstract

Novel therapies for clinical stage IIIA lung cancer are changing the outcomes in advanced clinical stage lung cancer. A 77-year-old female patient diagnosed with clinical T4 or stage IIIA right lower lobe adenocarcinoma with a KRAS mutation. She received neoadjuvant chemoimmunotherapy for an 8 cm tumor, which showed a moderate response on imaging. The patient underwent robotic-assisted thoracoscopic right lower lobectomy and mediastinal lymph node dissection. The final pathology showed a complete response. Novel induction chemoimmunotherapy provides an opportunity to completely eradicate cancer and provides surgical therapy for patients with advanced lung cancer.

## Linked entities

- **Genes:** KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845]
- **Diseases:** lung cancer (MONDO:0005138), adenocarcinoma (MONDO:0004970)

## Full-text entities

- **Genes:** KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}
- **Diseases:** cancer (MESH:D009369), Lung Adenocarcinoma (MESH:D000077192), Stage IIIA (MESH:D062706), right lower lobe adenocarcinoma (MESH:D000230), lung cancer (MESH:D008175)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12520254/full.md

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Source: https://tomesphere.com/paper/PMC12520254