# Secondary Syphilis With Isolated Ocular Syphilis and Superimposed Corneal Abrasion: A Case Report

**Authors:** Brandon C Stevens, Amna Zolj, John Abernathy

PMC · DOI: 10.7759/cureus.92266 · Cureus · 2025-09-14

## TL;DR

A case report highlights how delayed diagnosis of ocular syphilis can lead to blindness, emphasizing the need for quick detection.

## Contribution

This case report raises awareness about the importance of considering ocular syphilis in patients with refractory unilateral eye symptoms.

## Key findings

- Ocular syphilis can present with unilateral blindness and uveitis, mimicking other ocular conditions.
- Delayed diagnosis due to misidentification as a corneal abrasion led to complications.
- Early detection is crucial to prevent permanent blindness from ocular syphilis.

## Abstract

Ocular syphilis is a rare and easily preventable disease that can progress quickly to permanent blindness. Symptoms can mimic other ocular pathologies and further delay diagnosis. The incidence of syphilis continues to rise each year and represents significant morbidity in high-risk communities. In this case, the patient presented with unilateral blindness, uveitis, and a maculopapular rash on the lower extremities. Initially, she was found to have a corneal abrasion, leading to a missed diagnosis of ocular syphilis and delayed treatment. This case brings awareness to ocular syphilis as a key diagnosis to consider in a patient with unilateral ocular pathology that is refractory to treatment. Quick diagnosis is essential to prevent progression to permanent blindness.

## Linked entities

- **Diseases:** syphilis (MONDO:0005976), uveitis (MONDO:0020283)

## Full-text entities

- **Diseases:** Ocular Syphilis (MESH:D013587), blindness (MESH:D001766), maculopapular rash (MESH:D005076), uveitis (MESH:D014605), Corneal Abrasion (MESH:D003316)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12519900/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12519900/full.md

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Source: https://tomesphere.com/paper/PMC12519900