# Biomimetic Total Synthesis of (±)-Lappaceolides A and B

## TL;DR

Scientists synthesized lappaceolides A and B in two steps using a biomimetic reaction, supporting their origin from a natural compound.

## Contribution

A novel two-step total synthesis of lappaceolides A and B using a biomimetic domino reaction.

## Key findings

- The synthesis used a vinylogous-Michael–oxa-Michael domino reaction with Cs2CO3 in 1,2-DCE.
- The reaction required elevated temperatures and precise kinetic control.
- The synthesis supports the hypothesis that lappaceolides are dimers of siphonodin.

## Abstract

The first total synthesis of lappaceolides A and B is
achieved
in two steps by using a biomimetic vinylogous-Michael–oxa-Michael
domino reaction. The domino reaction proceeds with Cs2CO3 in 1,2-DCE at elevated temperatures and requires careful
kinetic control. The total synthesis provides further proof of the
biosynthetic hypothesis of lappaceolides being dimers of the natural
product siphonodin.