# High-Sensitivity Cardiac Troponin I Following Gender-Affirming Hormone Therapy in Transgender Adults

**Authors:** Ada S. Cheung, Ingrid Bretherton, Shalem Y. Leemaqz, Sathya Perera Wedithanthrige, Leah Singh, Cherie Chiang

PMC · DOI: 10.1001/jamanetworkopen.2025.37205 · 2025-10-13

## TL;DR

The study investigates changes in a heart-related protein in transgender individuals undergoing hormone therapy compared to cisgender individuals.

## Contribution

It provides new insights into cardiac biomarker levels in transgender adults during hormone therapy.

## Key findings

- Transgender individuals showed changes in troponin I levels over 12 months.
- Levels were compared with those of cisgender men and women.
- Findings suggest potential cardiac implications of hormone therapy.

## Abstract

This case-control study examines high-sensitivity cardiac troponin I levels in transgender men and women over 12 months of gender affirming hormone theraoy compared with cisgender men and women

## Full-text entities

- **Genes:** TNNI3 (troponin I3, cardiac type) [NCBI Gene 7137] {aka CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI}
- **Diseases:** TIA (MESH:D002546), acute myocardial infarction (MESH:D009203), cardiac mass (MESH:D006331), cardiovascular death (MESH:D002318), liver disease (MESH:D008107), heart failure (MESH:D006333), confusion (MESH:D003221), thromboembolic disease (MESH:D013923), GAHT (MESH:D019968)
- **Chemicals:** Testosterone (MESH:D013739), estradiol (MESH:D004958), GAHT (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12519299/full.md

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Source: https://tomesphere.com/paper/PMC12519299